Response to muramyl dipeptide

Across TCGA patient cohorts, RNA activity of the Response to muramyl dipeptide pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIM, TNFSF4, and IFFO1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muramyl dipeptide activity versus VIM in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VIM →	+0.767	+0.248	.001	.007	2	10
PDAC	TNFSF4 →	+0.773	+0.326	<.001	<.001	3	8
BRCA	IFFO1 →	+0.585	+0.248	.001	.001	3	7
OV	TSHZ3 →	+0.704	+0.172	.003	.008	3	7
OV	DAB2 →	+0.885	+0.283	.003	<.001	3	7
OV	AXL →	+1.170	+0.296	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032495 vs VIM — HNSC

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