Response to muramyl dipeptide

Across TCGA pan-cancer cohorts, RNA activity of the Response to muramyl dipeptide pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Response to muramyl dipeptide pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and ESCA, show the opposite pattern, with higher activity associated with better survival.

UCEC, HNSC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.530	0.801	<.001	108	view →
HNSC	DFS	Median	II,III,IV	0.666	0.531	<.001	77	view →
KIRC	DFS	Median	All	0.542	0.701	<.001	67	view →
ESCA	DFS	Median	III,IV	0.581	0.298	<.001	36	view →
COAD	DFS	Median	All	0.421	0.597	.002	34	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	22	view →
KICH	OS	Median	III,IV	0.125	0.815	<.001	22	view →
LUSC	DFS	Median	All	0.707	0.796	.010	20	view →
ACC	OS	Quartile	II,III,IV	0.584	0.956	.006	16	view →
UVM	DFS	Median	All	0.299	0.629	.027	16	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →
LGG	DFS	Quartile	All	0.776	0.886	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0032495–UCEC (OS)

Open the UCEC breakdown →