Response to muramyl dipeptide

Across TCGA cell cohorts, RNA activity of the Response to muramyl dipeptide pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL3, EFHD2, and TPRA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL3 grouped by Response to muramyl dipeptide-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ST3GAL3 →	-1.037	-1.147	.008	.002	3	4
LUNG_NSCLC_LUSC	EFHD2 →	-1.823	-0.730	<.001	.006	3	4
LARGE_INTESTINE	TPRA1 →	-0.416	-0.698	.005	.003	3	4
BLOOD_Lymphoma	ANKRD42 →	-1.685	-0.374	.009	.008	3	4
LIVER	CLMP →	-3.646	-1.486	.007	.004	3	4
BREAST	LIX1L →	-1.334	-0.601	.004	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL3 by Response to muramyl dipeptide activity — PANCREAS

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