Response to muramyl dipeptide

Across TCGA cell cohorts, RNA activity of the Response to muramyl dipeptide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, ESRP1, and CDS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muramyl dipeptide activity versus GPR176 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR176 →	+1.760	+0.636	<.001	.004	3	7
LUNG_NSCLC_LUAD	ESRP1 →	-1.855	-0.551	.006	.001	3	7
LUNG_NSCLC_LUAD	CDS1 →	-1.425	-0.636	.005	.008	3	7
BREAST	MARVELD3 →	-2.380	-1.051	.001	.002	3	6
STOMACH	LRP12 →	+2.074	+0.952	.001	.008	3	6
STOMACH	KDF1 →	-1.903	-1.012	.003	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032495 vs GPR176 — LUNG_NSCLC_LUAD

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