Response to peptidoglycan

Across TCGA cell cohorts, RNA activity of the Response to peptidoglycan pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL9A3, ALMS1, and SCARB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to peptidoglycan activity versus COL9A3 in SKIN (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COL9A3 →	-2.541	-0.190	<.001	<.001	3	7
BLOOD_Lymphoma	ALMS1 →	-0.910	-0.214	<.001	<.001	3	7
CNS	SCARB1 →	-0.950	-0.205	.002	.001	3	6
LUNG_SCLC	C1GALT1C1L →	-0.921	-0.174	.006	.004	2	7
BLOOD_Lymphoma	MICAL2 →	+1.624	+0.185	.003	.002	3	6
OVARY	OAT →	-0.542	-0.152	.003	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032494 vs COL9A3 — SKIN

Explore this scatter interactively →