Response to bacterial lipoprotein

Across TCGA patient cohorts, RNA activity of the Response to bacterial lipoprotein pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP31, CD36, and MSN, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to bacterial lipoprotein activity versus ARHGAP31 in OV (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP31 →	+0.807	+0.209	.001	<.001	3	8
BRCA	CD36 →	+1.379	+0.160	<.001	<.001	3	7
LSCC	MSN →	+0.414	+0.084	.003	.002	3	7
LSCC	SPOCD1 →	+0.614	+0.101	<.001	<.001	3	7
BRCA	PMP22 →	+0.781	+0.169	<.001	<.001	3	6
BRCA	MAN1C1 →	+0.646	+0.171	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032493 vs ARHGAP31 — OV

Explore this scatter interactively →