Cdc42 protein signal transduction

Across TCGA patient cohorts, RNA activity of the Cdc42 protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR4, FCGR2A, and ABCA1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cdc42 protein signal transduction activity versus TLR4 in LAML (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TLR4 →	+1.529	+0.050	<.001	<.001	2	33
DLBC	FCGR2A →	+1.531	+0.055	<.001	<.001	3	32
UCS	ABCA1 →	+1.569	+0.105	<.001	<.001	3	32
KICH	MS4A7 →	+1.791	+0.053	<.001	<.001	3	32
COAD	ITGAM →	+1.294	+0.062	<.001	<.001	3	32
DLBC	CD163 →	+2.240	+0.049	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032488 vs TLR4 — LAML

Explore this scatter interactively →