Cdc42 protein signal transduction

Across TCGA patient cohorts, RNA activity of the Cdc42 protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSL, NSA2P3, and ATP1A1-AS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cdc42 protein signal transduction activity versus CTSL in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CTSL →	+0.680	+0.123	.005	.005	3	5
UCEC	NSA2P3 →	-0.646	-0.146	.001	<.001	3	4
LUAD	ATP1A1-AS1 →	-0.671	-0.137	<.001	<.001	3	4
LUAD	FAM13A-AS1 →	-0.319	-0.129	.003	.003	3	4
UCEC	ETV1 →	-0.725	-0.201	.001	<.001	3	3
COAD	GPA33 →	+0.841	+0.120	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032488 vs CTSL — UCEC

Explore this scatter interactively →