Cdc42 protein signal transduction

Across TCGA cell cohorts, RNA activity of the Cdc42 protein signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1A, GRB14, and DHX40, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KDM1A grouped by Cdc42 protein signal transduction-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KDM1A →	+0.233	+0.699	<.001	.002	3	5
SKIN	GRB14 →	+0.268	+0.834	<.001	.003	3	3
SOFT_TISSUE	DHX40 →	+0.277	+1.618	.009	<.001	3	3
SOFT_TISSUE	CEPT1 →	-0.216	-1.147	.002	.002	3	3
SOFT_TISSUE	KCNIP1 →	+0.216	+1.127	.007	.002	3	3
BLOOD_Lymphoma	ALG5 →	-0.493	-0.537	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KDM1A by Cdc42 protein signal transduction activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →