Regulation of Rab protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rab protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPP6, PLOD1, and XBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rab protein signal transduction activity versus PLPP6 in COAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLPP6 →	+0.316	+0.217	.001	.005	3	5
BRCA	PLOD1 →	-0.875	-0.820	<.001	<.001	3	5
BRCA	XBP1 →	+1.172	+0.678	<.001	<.001	3	4
LSCC	MS4A4E →	+0.808	+0.523	<.001	.003	3	4
PDAC	ABCB1 →	+0.588	+0.138	<.001	.005	3	4
COAD	NPM3 →	-0.496	-0.249	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032483 vs PLPP6 — COAD

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