Otolith morphogenesis

Across TCGA patient cohorts, RNA activity of the Otolith morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR19, TBC1D24, and BBS7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otolith morphogenesis activity versus WDR19 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR19 →	+0.420	+0.095	<.001	<.001	3	6
BRCA	TBC1D24 →	+0.401	+0.041	.001	.008	3	5
BRCA	BBS7 →	+0.401	+0.056	<.001	<.001	3	5
LSCC	WDR35 →	+0.219	+0.061	<.001	<.001	3	5
LSCC	IFT122 →	+0.255	+0.059	<.001	<.001	3	5
HNSC	NDRG1 →	-0.510	-0.068	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032474 vs WDR19 — LSCC

Explore this scatter interactively →