Otolith morphogenesis

Across TCGA patient cohorts, RNA activity of the Otolith morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGR2, VIL1, and STK33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Otolith morphogenesis activity versus AGR2 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AGR2 →	+1.773	+0.612	.006	.001	3	4
CCRCC	VIL1 →	+1.207	+0.108	.001	<.001	3	3
CCRCC	STK33 →	+1.496	+0.141	<.001	<.001	3	3
CCRCC	LARP6 →	-0.609	-0.146	.003	.004	3	3
CCRCC	STX18 →	+0.458	+0.155	<.001	.002	3	3
GBM	LRIG1 →	+0.489	+0.339	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032474 vs AGR2 — UCEC

Explore this scatter interactively →