Otolith morphogenesis

Across TCGA cell cohorts, RNA activity of the Otolith morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMPR, ARPIN, and TRANK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GMPR grouped by Otolith morphogenesis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GMPR →	+0.991	+0.360	.008	.003	3	5
LUNG_SCLC	ARPIN →	+1.655	+0.454	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	TRANK1 →	+2.670	+1.652	<.001	.002	3	4
LARGE_INTESTINE	NDUFAF3 →	+0.502	+0.662	.005	.004	3	4
LUNG_NSCLC_LUAD	PROS1 →	+1.564	+0.709	.008	.006	3	4
LUNG_NSCLC_LUAD	TRAF4 →	-0.838	-0.788	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GMPR by Otolith morphogenesis activity — OESOPHAGUS

Explore this box plot interactively →