Negative regulation of endoplasmic reticulum calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Negative regulation of endoplasmic reticulum calcium ion concentration pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SP100, UBA7, and EVL_S246, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum calcium ion concentration activity versus SP100 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SP100 →	+0.393	+0.082	<.001	<.001	3	9
LSCC	UBA7 →	+0.375	+0.068	<.001	<.001	3	8
LSCC	EVL_S246 →	+0.514	+0.060	<.001	<.001	3	8
CCRCC	GBP2 →	+0.539	+0.056	<.001	<.001	3	8
GBM	LCP2 →	+0.493	+0.069	<.001	<.001	3	8
LSCC	IFIH1_S301 →	+0.754	+0.076	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032471 vs SP100 — LSCC

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