Negative regulation of endoplasmic reticulum calcium ion concentration

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of endoplasmic reticulum calcium ion concentration pathway differs between tumor and matched normal tissue in 10 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and PAAD, show the opposite pattern, with lower activity in tumor tissue.

KICH, LIHC, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	All	II,III,IV	−0.056	<.001	6	view →
LIHC	All	II,III,IV	+0.048	.001	6	view →
HNSC	All	All	+0.024	.008	5	view →
CHOL	All	All	+0.061	<.001	2	view →
ESCA	All	II,III,IV	+0.049	.019	2	view →
PAAD	Female	All	−0.035	.019	2	view →
UCEC	All	IV	+0.024	.037	2	view →
BRCA	All	IV	+0.024	.037	2	view →
PRAD	All	All	+0.020	.005	2	view →
LUAD	All	All	+0.017	.007	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 10 strongest of 10 lineages.

GO:0032471–KICH

Open the KICH breakdown →