Negative regulation of endoplasmic reticulum calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Negative regulation of endoplasmic reticulum calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRM2B, PDCD5, and DLL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum calcium ion concentration activity versus RRM2B in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RRM2B →	+0.398	+0.086	<.001	<.001	3	5
OV	PDCD5 →	-0.623	-0.150	.001	<.001	3	4
GBM	DLL1 →	-0.943	-0.082	.005	.007	3	4
PDAC	IFIT2 →	+0.771	+0.140	.002	.001	3	4
PDAC	WBP1 →	-0.332	-0.112	<.001	.003	3	4
LUAD	TRIM38 →	+0.239	+0.147	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032471 vs RRM2B — GBM

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