Negative regulation of endoplasmic reticulum calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Negative regulation of endoplasmic reticulum calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYLIP, CEP72, and ATP5F1E, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum calcium ion concentration activity versus MYLIP in LUNG_NSCLC_LUAD (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYLIP →	-1.517	-0.195	.006	.007	2	2
SKIN	CEP72 →	-1.015	-1.841	.008	.005	3	1
SKIN	ATP5F1E →	+1.095	+1.580	.002	.005	2	2
SKIN	TMEM251 →	-1.085	-1.887	.007	.002	3	1
SKIN	FRZB →	-0.345	-1.887	<.001	.002	3	1
SKIN	MAPK1IP1L →	-0.424	-1.748	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032471 vs MYLIP — LUNG_NSCLC_LUAD

Explore this scatter interactively →