Endoplasmic reticulum calcium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum calcium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LTBP2, SYNPO2, and CLUH, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum calcium ion homeostasis activity versus LTBP2 in CCRCC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LTBP2 →	+0.814	+0.043	.004	<.001	3	9
GBM	SYNPO2 →	+0.886	+0.072	<.001	<.001	3	8
LSCC	CLUH →	-0.423	-0.055	<.001	<.001	3	8
CCRCC	FBLN5 →	+0.775	+0.032	<.001	<.001	3	8
HNSC	LMOD1_S85 →	+0.724	+0.062	<.001	.009	3	8
GBM	GSN →	+0.574	+0.038	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032469 vs LTBP2 — CCRCC

Explore this scatter interactively →