Endoplasmic reticulum calcium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum calcium ion homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAOK1, CNOT4, and RNF40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TAOK1 grouped by Endoplasmic reticulum calcium ion homeostasis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TAOK1 →	-0.326	-0.134	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	CNOT4 →	-0.203	-0.133	.001	<.001	3	5
BLOOD_Myeloma	RNF40 →	-0.570	-0.105	<.001	.006	3	5
OESOPHAGUS	NECTIN3 →	-0.183	-0.122	<.001	.001	3	4
OESOPHAGUS	GPR20 →	+0.120	+0.130	.004	.004	3	4
OVARY	RPS7 →	+0.230	+0.090	.004	.006	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAOK1 by Endoplasmic reticulum calcium ion homeostasis activity — CNS

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