Negative regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIF1_S782, UNG_T60, and TOP2A_S1247, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cytokinesis activity versus RIF1_S782 in BRCA (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RIF1_S782 →	+0.976	+0.089	<.001	<.001	3	10
LUAD	UNG_T60 →	+0.825	+0.095	<.001	<.001	3	10
LUAD	TOP2A_S1247 →	+1.307	+0.112	<.001	<.001	3	10
GBM	POLD1 →	+0.438	+0.145	<.001	<.001	3	10
LUAD	RFC1_S368 →	+0.958	+0.121	<.001	<.001	3	9
GBM	RFC2 →	+0.400	+0.113	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032466 vs RIF1_S782 — BRCA

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