Regulation of cytokinesis

Across TCGA patient cohorts, RNA activity of the Regulation of cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, TACC3_S71, and TOP2A_S1247, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cytokinesis activity versus RPL12_S38 in LSCC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL12_S38 →	+0.991	+0.060	<.001	<.001	3	9
LUAD	TACC3_S71 →	+1.120	+0.064	<.001	<.001	3	9
LUAD	TOP2A_S1247 →	+1.342	+0.072	<.001	<.001	3	9
LUAD	RRM2 →	+0.814	+0.070	<.001	<.001	3	9
HNSC	ATAD2 →	+0.586	+0.079	<.001	.001	3	9
GBM	SMC2 →	+0.594	+0.061	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032465 vs RPL12_S38 — LSCC

Explore this scatter interactively →