Regulation of protein oligomerization

Across TCGA patient cohorts, RNA activity of the Regulation of protein oligomerization pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCER1A, GMDS, and RNU6-446P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein oligomerization activity versus FCER1A in PDAC (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FCER1A →	-0.908	-0.073	<.001	.004	3	4
LSCC	GMDS →	-0.404	-0.153	.001	.003	3	3
GBM	RNU6-446P →	-0.639	-0.133	.004	.003	3	3
GBM	RBM20 →	-0.537	-0.169	.003	.001	3	3
CCRCC	GLI1 →	-0.324	-0.143	.005	.003	3	3
CCRCC	SVEP1 →	-0.729	-0.132	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032459 vs FCER1A — PDAC

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