RNA, U6 small nuclear 446, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-446P profile across patient tissues and cancer cell-line models. RNU6-446P expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, RNU6-446P is differentially expressed in 4, with the highest sampling consensus in THCA. Additionally, RNU6-446P RNA expression shows 11,895 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight BLCA, THCA, and THYM as cancer lineages where RNU6-446P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-446P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-446P survival associations across molecular data types. RNU6-446P RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-446P RNA expression–survival associations across cancer types. High RNU6-446P expression shows unfavorable associations in LGG, ACC, LIHC and KIRC, but favorable associations in BLCA and LAML. The BLCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify BLCA as the clearest survival context for RNU6-446P RNA expression.
This table summarizes RNU6-446P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-446P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-446P shows lower tumor expression in PAAD and LUSC and higher tumor expression in THCA and CHOL. The THCA box plot shows higher RNU6-446P RNA expression in tumor versus normal tissue (log2 FC = +0.271, t-test p < 0.001).
This table shows molecular features associated with RNU6-446P in patient tissues and cancer cell lines. In patient samples, RNU6-446P shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
