Endocytic recycling

Across TCGA patient cohorts, RNA activity of the Endocytic recycling pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRPF4B_S294, SNW1_S224, and SPEN_S1006, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocytic recycling activity versus PRPF4B_S294 in LSCC (Pearson r = -0.82).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRPF4B_S294 →	-1.042	-0.150	<.001	<.001	3	5
LUAD	SNW1_S224 →	-0.436	-0.138	<.001	.001	3	4
UCEC	SPEN_S1006 →	-0.572	-0.228	<.001	<.001	3	4
LSCC	TOP2A →	-0.841	-0.186	<.001	<.001	3	4
LSCC	TOP2A_S1106 →	-0.893	-0.160	<.001	<.001	3	4
LSCC	NIBAN2_S665 →	+0.617	+0.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032456 vs PRPF4B_S294 — LSCC

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