Negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WRNIP1_S78, ZYX, and RIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of proteasomal ubiquitin-dependent protein catabolic process activity versus WRNIP1_S78 in OV (Pearson r = 0.88).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WRNIP1_S78 →	+2.031	+0.060	.004	.009	3	4
OV	ZYX →	+0.323	+0.035	.001	<.001	3	4
LSCC	RIF1 →	+0.432	+0.042	.001	.001	3	4
LSCC	TOP2A_S1377 →	+0.928	+0.046	.001	<.001	3	4
LSCC	ADI1 →	+0.402	+0.046	.001	<.001	3	4
HNSC	MSH2 →	+0.291	+0.052	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032435 vs WRNIP1_S78 — OV

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