Negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPH5, CAB39L, and CHST5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPH5 grouped by Negative regulation of proteasomal ubiquitin-dependent protein catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DPH5 →	-0.749	-0.276	.004	.006	3	4
BREAST	CAB39L →	+0.983	+0.159	.005	.007	3	4
BLOOD_Lymphoma	CHST5 →	+0.250	+0.425	.006	.005	2	5
STOMACH	KIF20B →	-0.775	-0.154	.001	.003	2	5
SKIN	VIRMA →	-0.415	-0.166	.002	.005	3	4
SKIN	FAM131A →	+0.736	+0.126	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPH5 by Negative regulation of proteasomal ubiquitin-dependent protein catabolic process activity — LUNG_SCLC

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