Positive regulation of transporter activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of transporter activity pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDC4, HSPD1, and APOL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transporter activity activity versus SDC4 in SOFT_TISSUE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SDC4 →	+3.225	+0.474	.001	<.001	3	8
STOMACH	HSPD1 →	-0.798	-0.663	<.001	.001	3	8
OVARY	APOL1 →	+3.716	+0.442	.003	.001	3	8
SKIN	EEF1B2 →	-0.541	-0.322	.002	.002	3	7
BONE	ATP5F1B →	-0.991	-0.589	<.001	<.001	3	7
STOMACH	MYG1 →	-0.650	-0.487	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032411 vs SDC4 — SOFT_TISSUE

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