Negative regulation of intracellular transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of intracellular transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, SH3D19, and FERMT2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intracellular transport activity versus SORBS1 in HNSC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SORBS1 →	+0.693	+0.068	<.001	<.001	3	9
BRCA	SH3D19 →	+0.398	+0.031	<.001	<.001	3	9
COAD	FERMT2 →	+0.634	+0.033	<.001	<.001	3	9
BRCA	MSRB3 →	+0.683	+0.034	<.001	<.001	3	9
HNSC	PRKG1 →	+0.591	+0.077	<.001	<.001	3	9
HNSC	SYNPO2 →	+1.018	+0.040	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032387 vs SORBS1 — HNSC

Explore this scatter interactively →