Regulation of intracellular lipid transport

Across TCGA patient cohorts, RNA activity of the Regulation of intracellular lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, FAM114A1, and AHNAK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intracellular lipid transport activity versus ITGA3 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGA3 →	+0.856	+0.567	.007	.005	3	4
BRCA	FAM114A1 →	+0.373	+0.451	.002	.002	3	4
LSCC	AHNAK →	+0.575	+0.636	<.001	<.001	3	4
LUAD	E2F5 →	-0.310	-0.407	.001	.005	3	4
BRCA	ANXA2 →	+0.626	+0.576	<.001	<.001	3	4
BRCA	PPL →	+0.773	+0.560	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032377 vs ITGA3 — OV

Explore this scatter interactively →