Regulation of intracellular lipid transport

Across TCGA cell cohorts, RNA activity of the Regulation of intracellular lipid transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF274, PUS3, and BACH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF274 grouped by Regulation of intracellular lipid transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZNF274 →	+1.073	+1.507	.001	<.001	3	4
BLOOD_Leukemia	PUS3 →	+1.096	+1.403	.001	.003	3	4
OESOPHAGUS	BACH1 →	+0.875	+1.124	.001	.003	3	4
CNS	ITPR3 →	-1.919	-1.044	.001	.002	3	4
LUNG_NSCLC_LUAD	MYEF2 →	+1.475	+1.004	.009	<.001	3	3
LUNG_NSCLC_LUAD	RAB5C →	-0.405	-0.860	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF274 by Regulation of intracellular lipid transport activity — KIDNEY

Explore this box plot interactively →