Negative regulation of sterol transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of sterol transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are REPS2, SGSM3, and PLEKHA7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sterol transport activity versus REPS2 in LUAD (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	REPS2 →	+0.264	+0.058	<.001	.003	3	5
PDAC	SGSM3 →	+0.472	+0.059	<.001	<.001	3	4
LUAD	PLEKHA7 →	+0.239	+0.044	.001	.001	3	4
LSCC	SORL1 →	+0.266	+0.064	.007	.001	3	4
PDAC	ARFIP1 →	+0.216	+0.049	<.001	.007	3	4
UCEC	TJP3 →	+0.419	+0.105	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032372 vs REPS2 — LUAD

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