Negative regulation of sterol transport

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of sterol transport pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BRCA and CHOL, show the opposite pattern, with lower activity in tumor tissue.

KICH, COAD, and BRCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Female	All	+0.239	<.001	10	view →
COAD	All	All	+0.067	<.001	8	view →
BRCA	Female	All	−0.055	<.001	6	view →
CHOL	Male	All	−0.263	<.001	5	view →
THCA	All	All	+0.064	.001	5	view →
LUAD	Female	All	−0.051	<.001	5	view →
BLCA	All	All	−0.066	.011	4	view →
KIRP	Male	All	+0.066	.001	3	view →
LIHC	Male	II,III,IV	−0.052	.004	3	view →
STAD	Male	II,III,IV	−0.052	.027	2	view →
PRAD	All	All	+0.046	<.001	2	view →
READ	All	All	+0.056	.016	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0032372–KICH

Open the KICH breakdown →