Negative regulation of sterol transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANTXR2, ABI3, and GIMAP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sterol transport activity versus ANTXR2 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANTXR2 →	+0.723	+0.086	<.001	.004	3	6
UCEC	ABI3 →	+0.596	+0.115	.003	<.001	3	4
UCEC	GIMAP6 →	+0.839	+0.117	<.001	.004	3	4
UCEC	GYPC →	+0.788	+0.144	<.001	<.001	3	4
UCEC	GIMAP7 →	+1.077	+0.112	<.001	.004	3	4
UCEC	ITGA8 →	+0.661	+0.109	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032372 vs ANTXR2 — UCEC

Explore this scatter interactively →