Negative regulation of sterol transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G0S2, DOCK10, and TRERF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, G0S2 grouped by Negative regulation of sterol transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	G0S2 →	-4.726	-1.752	.005	<.001	3	5
LIVER	DOCK10 →	-3.100	-1.250	.001	.001	3	5
PANCREAS	TRERF1 →	-1.013	-1.110	<.001	.001	3	5
SOFT_TISSUE	AHI1 →	-1.485	-1.346	.008	<.001	3	4
LIVER	PPP1R18 →	-2.413	-1.411	.006	.002	3	4
LIVER	MAGEF1 →	+1.015	+1.421	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

G0S2 by Negative regulation of sterol transport activity — LIVER

Explore this box plot interactively →