Negative regulation of sterol transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KDM1B, CNTNAP3C, and PARP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of sterol transport activity versus KDM1B in PANCREAS (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KDM1B →	+1.057	+1.255	.006	.001	3	4
LUNG_NSCLC_LUAD	CNTNAP3C →	-1.070	-1.352	.002	<.001	3	4
LUNG_NSCLC_LUSC	PARP4 →	-1.519	-1.322	.007	.008	3	3
LUNG_NSCLC_LUSC	AHR →	-1.690	-1.397	.005	<.001	3	3
LUNG_NSCLC_LUSC	SLC16A14 →	-3.208	-1.320	.004	<.001	3	3
OESOPHAGUS	POLD2 →	-0.690	-1.113	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032372 vs KDM1B — PANCREAS

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