Intracellular sterol transport

Across TCGA cell cohorts, RNA activity of the Intracellular sterol transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNT1, CHAF1B, and E2F5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNT1 grouped by Intracellular sterol transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCNT1 →	+0.598	+1.029	.003	.006	3	5
BLOOD_Leukemia	CHAF1B →	+0.793	+0.965	<.001	.001	3	4
BLOOD_Leukemia	E2F5 →	+1.391	+1.350	<.001	<.001	3	4
BLOOD_Leukemia	ATL2 →	+0.689	+1.033	.001	.008	3	4
OVARY	POLR3D →	+0.864	+0.784	<.001	.002	3	4
BLOOD_Leukemia	ANKRD52 →	+1.122	+1.432	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNT1 by Intracellular sterol transport activity — BLOOD_Leukemia

Explore this box plot interactively →