Intracellular oxygen homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the KICH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIAO3, MCRIP2, and ROGDI, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular oxygen homeostasis activity versus CIAO3 in KICH (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KICH	CIAO3 →	+0.581	+0.063	<.001	<.001	3	20
MESO	MCRIP2 →	+0.735	+0.060	.004	<.001	2	18
MESO	ROGDI →	+0.812	+0.066	<.001	<.001	3	17
THYM	RHBDL1 →	+1.429	+0.053	.001	<.001	2	17
MESO	CHSY1 →	-0.896	-0.057	<.001	<.001	3	14
DLBC	HAGHL →	+1.098	+0.076	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032364 vs CIAO3 — KICH

Explore this scatter interactively →