Intracellular oxygen homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIAP67, SLC10A1, and SDK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular oxygen homeostasis activity versus PPIAP67 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPIAP67 →	+0.618	+0.184	<.001	<.001	3	4
LSCC	SLC10A1 →	+0.286	+0.098	.005	.006	3	3
HNSC	SDK1 →	+0.716	+0.170	<.001	.003	3	3
LSCC	REC114 →	+0.321	+0.105	.001	.003	3	3
LSCC	LINC02818 →	+0.493	+0.172	.003	<.001	3	3
GBM	IL24 →	-0.289	-0.177	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032364 vs PPIAP67 — LSCC

Explore this scatter interactively →