Intracellular oxygen homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIPEP, C2orf49, and LRRC37A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MIPEP grouped by Intracellular oxygen homeostasis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MIPEP →	-0.890	-1.695	.006	<.001	3	4
BLOOD_Myeloma	C2orf49 →	+0.767	+0.829	.002	.005	3	3
PANCREAS	LRRC37A3 →	+1.275	+0.762	.003	.009	3	3
BREAST	GLE1 →	+0.762	+0.618	<.001	.003	3	3
LUNG_SCLC	S100A13 →	-2.303	-1.012	<.001	.009	3	3
LUNG_NSCLC_LUSC	DNAJB2 →	-0.883	-0.262	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MIPEP by Intracellular oxygen homeostasis activity — BLOOD_Lymphoma

Explore this box plot interactively →