Intracellular oxygen homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECD, IGFBP6, and ACO1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular oxygen homeostasis activity versus ECD in STOMACH (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ECD →	-0.653	-0.341	.006	.002	3	4
BREAST	IGFBP6 →	+3.237	+0.655	<.001	.002	3	3
CNS	ACO1 →	+0.976	+0.228	.006	.002	3	3
CNS	MAP3K7CL →	+2.600	+0.211	<.001	.007	3	3
CNS	CD82 →	+2.835	+0.244	.002	.001	3	3
LARGE_INTESTINE	LRRIQ3 →	-0.666	-0.156	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032364 vs ECD — STOMACH

Explore this scatter interactively →