Intracellular oxygen homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular oxygen homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOD2, NNT, and NDUFA10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular oxygen homeostasis activity versus SOD2 in OVARY (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SOD2 →	+2.051	+0.423	.004	<.001	3	9
OVARY	NNT →	+2.526	+0.515	.001	<.001	3	9
SKIN	NDUFA10 →	+0.734	+0.308	<.001	<.001	3	6
SKIN	OGDH →	+0.882	+0.326	<.001	<.001	3	6
SKIN	SLC25A3 →	+0.749	+0.240	<.001	<.001	3	6
LUNG_SCLC	RPLP2 →	-0.589	-0.227	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032364 vs SOD2 — OVARY

Explore this scatter interactively →