Response to estradiol

Across TCGA cell cohorts, RNA activity of the Response to estradiol pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM10, FBXO10, and LRATD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM10 grouped by Response to estradiol-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LSM10 →	-0.504	-0.136	.005	.008	3	6
URINARY_TRACT	FBXO10 →	-1.383	-0.154	<.001	.001	3	5
OESOPHAGUS	LRATD2 →	+1.532	+0.133	.001	<.001	3	5
URINARY_TRACT	EPS8L1 →	+4.396	+0.154	<.001	.001	2	5
URINARY_TRACT	TMPRSS4 →	+4.735	+0.154	.002	.001	3	4
URINARY_TRACT	NECTIN4 →	+4.093	+0.154	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM10 by Response to estradiol activity — LARGE_INTESTINE

Explore this box plot interactively →