Response to follicle-stimulating hormone

Across TCGA patient cohorts, RNA activity of the Response to follicle-stimulating hormone pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN1, SPOCK1, and VSTM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to follicle-stimulating hormone activity versus CAVIN1 in BRCA (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN1 →	+1.038	+0.508	<.001	<.001	3	4
GBM	SPOCK1 →	+1.277	+0.616	<.001	.005	3	3
BRCA	VSTM4 →	+0.920	+0.430	<.001	<.001	3	3
OV	MAP2K5 →	+0.400	+0.452	.001	.002	3	3
OV	MYOM3 →	+0.577	+0.415	.009	.002	3	3
OV	DPYSL4 →	+0.954	+0.480	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032354 vs CAVIN1 — BRCA

Explore this scatter interactively →