Positive regulation of hormone metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of hormone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FXYD5, CD68, and ATP23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FXYD5 grouped by Positive regulation of hormone metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FXYD5 →	-2.853	-0.641	.001	.005	3	5
BREAST	CD68 →	-2.062	-0.564	<.001	.002	3	4
BREAST	ATP23 →	+0.694	+0.846	.008	<.001	3	4
BREAST	CEBPB →	-0.861	-0.601	.003	.001	3	4
BREAST	TAP2 →	-1.229	-0.592	.005	.001	2	5
BLOOD_Lymphoma	SCNN1A →	-0.192	-1.949	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FXYD5 by Positive regulation of hormone metabolic process activity — BREAST

Explore this box plot interactively →