Regulation of aldosterone metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of aldosterone metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TASP1, FANCD2_S1435, and RSU1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of aldosterone metabolic process activity versus TASP1 in LUAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TASP1 →	+0.255	+0.090	.001	<.001	3	6
GBM	FANCD2_S1435 →	-0.831	-0.074	<.001	<.001	3	6
CCRCC	RSU1 →	+0.260	+0.081	<.001	<.001	3	6
OV	COL14A1 →	+0.822	+0.049	.001	.001	3	6
OV	AHNAK_T5824 →	+1.346	+0.055	.001	<.001	3	6
CCRCC	PRKG1 →	+0.414	+0.072	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032344 vs TASP1 — LUAD

Explore this scatter interactively →