Regulation of aldosterone metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of aldosterone metabolic process pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher Regulation of aldosterone metabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and CHOL, show the opposite pattern, with higher activity associated with better survival.

COAD, ACC, and SARC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.733	0.859	<.001	99	view →
ACC	OS	Quartile	All	0.314	0.813	<.001	61	view →
SARC	OS	Tertile	All	0.755	0.926	.001	25	view →
BLCA	OS	Tertile	All	0.508	0.649	.010	24	view →
MESO	DFS	Quartile	II,III,IV	0.819	0.242	.017	21	view →
DLBC	OS	Median	II,III,IV	0.379	0.947	.010	21	view →
LIHC	DFS	Quartile	All	0.460	0.619	.006	20	view →
CHOL	OS	Median	All	0.764	0.328	.004	15	view →
SKCM	OS	Median	IV	0.787	0.270	.014	13	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.643	.019	12	view →
UVM	OS	Median	III,IV	0.828	0.387	.025	9	view →
HNSC	DFS	Tertile	III,IV	0.754	0.609	.021	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0032344–COAD (OS)

Open the COAD breakdown →