Regulation of aldosterone metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of aldosterone metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP6, REST, and GABARAPL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP6 grouped by Regulation of aldosterone metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BMP6 →	-0.243	-0.655	<.001	<.001	3	6
LARGE_INTESTINE	REST →	-0.241	-1.233	<.001	<.001	3	5
OESOPHAGUS	GABARAPL3 →	+0.124	+1.265	.005	.005	3	4
LUNG_NSCLC_LUAD	DKK3 →	-0.120	-0.588	.006	.003	2	5
LUNG_NSCLC_LUSC	PRMT3 →	-0.150	-0.475	.007	.001	3	4
BREAST	BMP5 →	-0.102	-0.459	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP6 by Regulation of aldosterone metabolic process activity — BREAST

Explore this box plot interactively →