Regulation of chondrocyte differentiation

Across TCGA patient cohorts, RNA activity of the Regulation of chondrocyte differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GAL2, TRPS1, and ARMC9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chondrocyte differentiation activity versus ST6GAL2 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ST6GAL2 →	+0.958	+0.637	.001	<.001	3	7
BRCA	TRPS1 →	+1.345	+0.241	<.001	.001	3	6
BRCA	ARMC9 →	+0.598	+0.282	<.001	.001	3	6
BRCA	BBS5 →	+0.410	+0.165	<.001	.004	3	6
LSCC	DACT1 →	+0.867	+0.911	<.001	<.001	3	6
LSCC	VSTM4 →	+0.592	+0.737	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032330 vs ST6GAL2 — HNSC

Explore this scatter interactively →