Alanine transport

Across TCGA cell cohorts, RNA activity of the Alanine transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRC2A, LRP1, and CCDC58, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRRC2A grouped by Alanine transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRRC2A →	+0.393	+1.391	.007	<.001	3	4
PANCREAS	LRP1 →	-2.366	-1.238	<.001	.002	3	4
PANCREAS	CCDC58 →	+0.440	+0.974	.007	.001	3	4
BLOOD_Lymphoma	RCE1 →	+0.616	+1.644	.001	.004	1	6
BLOOD_Myeloma	SEC22C →	+0.949	+1.491	.001	.002	2	5
STOMACH	NCAPG →	+0.941	+1.515	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRRC2A by Alanine transport activity — BLOOD_Leukemia

Explore this box plot interactively →