Regulation of icosanoid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of icosanoid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILF2, SSRP1, and SUPT16H, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of icosanoid secretion activity versus ILF2 in LSCC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ILF2 →	-0.215	-0.057	.002	<.001	3	7
LSCC	SSRP1 →	-0.561	-0.078	<.001	<.001	3	6
LSCC	SUPT16H →	-0.467	-0.074	<.001	<.001	3	6
GBM	TLR2 →	+0.528	+0.083	<.001	<.001	3	6
OV	TOP2B →	-0.393	-0.051	.001	.001	3	6
LSCC	SF3B3 →	-0.259	-0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0032303 vs ILF2 — LSCC

Explore this scatter interactively →